Role of Tinospora Crispa accelerated Wound Healing Potential in Adult NursingName : Dr. Walaa Najm Abood
Affliation : Assistant professor
University : University of Diyala
Country : Iraq
Background: This research was conducted to help Adult nursing provide care for immunosuppressed people as diabetic patients by assessment the effect of medicinal plant Tinospora crispa (T. crispa) extract on closure rate of wound healing potential.
Methods: Twenty adult Sprague-Dawley rats were used in wound healing evaluation experiment and divided into 4 groups. Experimentally, Two-centimeter-diameter full-thickness skin excision wounds were created on the posterior neck area using round seal. The animal groups were topically treated with 0.2 mL gum acacia as vehicle control group, Intrasite gel as reference group, and 100 and 200 mg/mL of T. crispa stem extract, respectively as experimental groups. Granulation tissue was excised on the 15th day and processed for histological and biochemical analysis. Wound healing was evaluated by measuring wound contractions and protein contents in the healing wounds. Cellular redistribution and collagen deposition were assessed morphologically using Masson’s trichrome stain. The sera levels of TGF-β1 and TNF-α were evaluated for all the animals.
Results: Rats dressed with T. crispa extract showed significantly accelerated wound healing closure, increased TGF-β1 level, decreased TNF-α levels compared with the rats dressed with vehicle or Intrasite gel. Histology of wound healed area confirmed the results showing remarkable increase in collagen fiber, reduced leucocytes infiltration, while Masson’s Trichrome stained sections showed remarkable increased collagen fibers in T. crispa-dressed wounds.
Conclusions: The present study suggest a new topical treatment, that aid adult nursing to give helping for wounded immunosuppressed patients to accelerate wound healing process for enhancing cure process by using natural treatment without any side effect.
Biography: Walaa Najm Abood completed her PhD in medicine from University of Malaya in Malaysia. She is the Director of Postgraduate Section in College Council Secretary and Assistant Professor of Immunology in Medical Microbiology Department for College of Medicine in Diyala University, Iraq. She has published more than 15 papers in reputed journals and has been serving as an editorial board member and reviewer in the ISI journal.